Lorazepam, commonly known by the brand name Ativan, is a medication that is primarily used to treat anxiety disorders. It belongs to a class of drugs known as benzodiazepines, which act on the central nervous system to produce a calming effect. In addition to its primary use in treating anxiety, Ativan is also prescribed to treat insomnia and nausea, conditions often experienced by cancer patients.

Ativan enhances the effects of a natural chemical in the body (GABA), which contributes to its effectiveness in reducing nervous tension. This mechanism makes it not only suitable for those experiencing anxiety but also useful in helping cancer patients manage the symptoms and side effects associated with their disease and treatment. For example, cancer treatments such as chemotherapy can cause nausea and vomiting, whereas Ativan can be used to relieve these unwanted side effects

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Indications for use

The main indications for the use of Ativan are:

• neurosis-like and neurotic conditions accompanied by increased fatigue, anxiety, sleep disturbances, irritability, autonomic disorders;
• skeletal muscle hypertonicity of various origins;
• alcohol withdrawal syndrome - as part of combination therapy;
• long-term diagnostic procedures and operations - as premedication.

Contraindications

Absolute:

• states of anxiety or mental stress caused by everyday problems;
• severe respiratory failure of any origin
• sleep apnea syndrome;
• psychosis;
• severe liver and/or kidney failure;
• glaucoma;
• acute porphyria;
• myasthenia;
• alcohol poisoning;
• alcohol dependence (during and for three days after completion of treatment, alcoholic beverages must not be consumed);
• hereditary lactose or fructose intolerance, Lapp lactase or sucrase-isomaltase deficiency, glucose-galactose malabsorption syndrome;
• breastfeeding;
• age under 12 years;
• hypersensitivity to 1,4-benzodiazepine derivatives or components of the drug.

Ativan should be taken with caution in cases of mild to moderate liver and/or kidney failure, chronic respiratory failure, history of suicidal thoughts and attempts, depression, porphyria, cerebral and spinal ataxia, hyperkinesis, hypoproteinemia, organic pathologies of the brain, history of alcohol, drug or drug addiction, in old age, during pregnancy.

Method of administration

Ativan Generic pills are taken orally. Doses should be selected individually, and clinical symptoms and tolerability of lorazepam should be constantly monitored.

Adult patients with anxiety are usually prescribed 1–2 mg of Ativan up to 3 times a day.

Adult patients with insomnia are usually prescribed 1–4 mg of Ativan 30 minutes before bedtime.

As a premedication before the onset of anesthesia, adult patients are given 2.5–5 mg of Ativan once.

Lorazepam is prescribed to children only in premedication regimens before the onset of anesthesia; in such cases, it is recommended to prescribe 0.5–2.5 mg of Ativan 60 minutes before the onset of surgery (doses are indicated for children aged 5–13 years).

Elderly individuals should reduce the dose of Ativan by 50% (compared to standard doses of lorazepam recommended for adult patients).

Individuals with altered renal function should have their dose of Ativan adjusted based on the filtration rate.